trientine (Cuprid, Tecza, Syprine)

Trientine hydrochloride. N,N'-bis (2-aminoethyl-1,2-ethane-diamine dihydrochloride [NH2-(CH2)2-NH-(CH2)2-NH-(CH2)2-NH2] * 2HCl C6H18N4 * 2HCl Indications: 1) hepatolenticular degeneration (Wilson's disease) 2) not recommended for rheumatoid arthritis or cystinuria Dosage: 1) start: 750-1250 mg QD divided TID or QID; max: 2 g/day 2) start: 500-750 mg PO QD in children; max 1.5 g/day 3) take on empty stomach - 1 hour before meals, or 2 hours after meals 4) average effective daily dose: 1-2 g Capsules: 250 mg Adverse effects: 1) iron deficiency 2) recurrence of prior symptoms of lupus erythematosus 3) pregnancy category C: teratogenic in rats Mechanism of action: copper chelation

General

amine chelating agent

Properties

SIZE: MW = 148 G/MOL

References

Physician's Desk Reference (PDR) 42nd edition 1998