trichoplein keratin filament-binding protein; protein TCHP (TCHP)

Function: - may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery - may regulate K8/K18 filament & desmosome organization mainly at the apical or peripheral regions of simple epithelial cells - interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 & KRT18 Structure: belongs to the TCHP family Compartment: cytoplasm, cytoskeleton Expression: - expressed in all tissues examined including, brain, liver, small intestine, large intestine, lung & heart - in hepatocytes, found concentrated in tubular structures, in apical cortical region & desmosomes - in the apical junctional domain in enterocytes of the small intestine - in hair follicles, localized at the outer root sheath - also expressed in blood vessels

Properties

SIZE: MW = 61 kD entity length = 498 aa COMPARTMENT: cytoplasm MOTIF: coiled coil {11-39} coiled coil {66-136} glutamate-rich region {70-482} MOTIF: glutamate residue (SEVERAL) keratin proteins interaction {73-498} MOTIF: coiled coil {163-353} Trichohyalin/plectin homology {259-425} coiled coil {380-479}

References

UniProt :accession Q9BT92