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tricarboxylate transport protein, mitochondrial; citrate transport protein; CTP; tricarboxylate carrier protein; solute carrier family 25 member 1 (SLC25A1, SLC20A3)
Function:
- role in citrate-H+/malate exchange
- role in bioenergetics of hepatic cells as it provides a carbon source for fatty acid & sterol biosyntheses, & NAD+ for the glycolytic pathway
Structure:
- belongs to the mitochondrial carrier family
- contains 3 solcar repeats
Compartment: mitochondrial inner membrane
Pathology:
- reduced histone acetylation due to impaired export of mitochondrial acetyl-CoA with age in mesenchymal stem cells due to lower levels of citrate carrier [3]
Interactions
molecular events
General
mitochondrial membrane protein
permease
solute carrier family 25 (SLC25, SLC25A)
Properties
SIZE: entity length = 311 aa
MW = 34 kD
COMPARTMENT: inner mitochondrial membrane
MOTIF: Solcar {23-111}
MOTIF: transmembrane domain {29-46}
transmembrane domain {86-105}
Solcar {122-208}
MOTIF: transmembrane domain {129-143}
transmembrane domain {183-202}
Solcar {218-303}
MOTIF: transmembrane domain {224-241}
transmembrane domain {278-297}
Database Correlations
OMIM 190315
UniProt P53007
Pfam PF00153
Entrez Gene 6576
Kegg hsa:6576
References
- UniProt :accession P53007
- Principles of Biochemistry 6th ed., White, Handler,
Smith, Hill, & Lehman (eds.) McGraw-Hill, NY 1978, pg 345
- Pouikli A, Parekh S, Maleszewska M et al
Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis
of aged mesenchymal stem cells.
Nat Aging. 2021 Sep;1(9):810-825
PMID: 37117628 PMCID: PMC10154229 Free PMC article.
https://www.nature.com/articles/s43587-021-00105-8