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double-stranded telomeric DNA-binding TRF1 complex
Function:
- regulation of telomere length by cis-inhibition of telomerase
Structure:
- complex of POT1, TERF1, TINF2, TNKS1
General
molecular complex
Properties
SUBUNITS: POT1 protein
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
telomeric repeat-binding factor 1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acidic region {2-71}
MOTIF: acidic residue (SEVERAL)
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S11}
glutamate-rich region {55-62}
MOTIF: glutamate residue (SEVERAL)
TRFH dimerization {58-268}
MOTIF: Ser phosphorylation site {S219}
RLIM interaction {265-378}
MOTIF: nuclear translocation signal {337-356}
HTH myb-type {375-432}
MOTIF: DNA-binding motif
SITE: 403-428
Ser phosphorylation site {S434}
Ser phosphorylation site {S435}
Ser phosphorylation site {S437}
TERF1-interacting nuclear factor 2
COMPARTMENT: cell nucleus
MOTIF: TBM {256-278}
MOTIF: nuclear translocation signal {262-268}
Ser phosphorylation site {S295}
References
UniProt :accession Q9NUX5
Components
POT1 protein (protection of telomeres 1, POT1-like telomere end-binding protein)
telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1 (TERF1, PIN2, TRBF1, TRF1)
TERF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2 (TINF2, TIN2)