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heat shock protein 75 kD, mitochondrial; HSP 75; tumor necrosis factor type 1 receptor-associated protein; TRAP-1; TNFR-associated protein 1 (TRAP1, HSP75)
Function:
- chaperone that expresses an ATPase activity
- binds to the intracellular domain of TNF receptor 1
- binds to RB1
Structure: belongs to the heat shock protein 90 family
Compartment: mitochondria
Expression:
- found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung & placenta
Comparative biology:
- TRAP1 knockout mice show less age-related tissue degeneration, obesity, & spontaneous tumor formation & live longer than normal mice
General
heat shock protein [hsp]-90 family
mitochondrial protein
phosphoprotein
receptor
shortened longevity protein
Properties
SIZE: entity length = 704 aa
MW = 80 kD
COMPARTMENT: mitochondria
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 119-119
ATP-binding site
NAME: ATP-binding site
SITE: 158-158
ATP-binding site
NAME: ATP-binding site
SITE: 171-171
ATP-binding site
NAME: ATP-binding site
SITE: 205-205
Tyr phosphorylation site {Y366}
Ser phosphorylation site {S401}
Thr phosphorylation site {T494}
Database Correlations
OMIM 606219
UniProt Q12931
PFAM correlations
Entrez Gene 10131
Kegg hsa:10131
References
- UniProt :accession Q12931
- Lisanti S, Tavecchio M, Chae YC et al
Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global
Reprogramming of Metabolic Networks.
Cell Rep. 2014 Aug 7;8(3):671-7.
PMID: 25088416