trans-Golgi network integral membrane protein 2; TGN38 homolog; TGN46; TGN48; trans-Golgi network protein TGN51 (TGOLN2, TGN46, TGN51)

Function: - may be involved in regulating membrane traffic to & from the trans-Golgi network Compartment: - cell membrane; single-pass type 1 membrane protein - Golgi, trans-Golgi network membrane - primarily in trans-Golgi network - cycles between the trans-Golgi network & the cell surface returning via endosomes Alternative splicing: named isoforms=6; TGN51, TGN46, TGN48 Expression: - isoform TGN46 is widely expressed - isoform TGN51 is more abundant in fetal lung & kidney - isoform TGN48 is expressed at very low levels in embryonic kidney & promyelocytic cells

General

glycoprotein membrane protein phosphoprotein

Properties

SIZE: entity length = 480 aa MW = 51 kD COMPARTMENT: golgi MOTIF: signal sequence {1-21} N-glycosylation site {N39} 14 X 14 AA tandem repeats {54-249} MOTIF: consensus repeat {54-67} consensus repeat {68-81} Ser phosphorylation site {S70} Ser phosphorylation site {S71} consensus repeat {82-95} N-glycosylation site {N82} Ser phosphorylation site {S94} consensus repeat {96-109} N-glycosylation site {N96} Ser phosphorylation site {S98} consensus repeat {110-123} consensus repeat {124-137} consensus repeat {138-151} consensus repeat {152-165} N-glycosylation site {N152} consensus repeat {166-179} consensus repeat {180-193} N-glycosylation site {N180} consensus repeat {194-207} consensus repeat {208-221} N-glycosylation site {N208} consensus repeat {222-234} N-glycosylation site {N222} consensus repeat {235-249} Ser phosphorylation site {S298} Ser phosphorylation site {S314} Ser phosphorylation site {S315} Ser phosphorylation site {S351} Ser phosphorylation site {S362} Tyr phosphorylation site {Y371} N-glycosylation site {N373} N-glycosylation site {N377} transmembrane domain {382-402} Endocytosis signal; in isoform TGN46 and isoform TGN48 {430-433} Endocytosis signal; in isoform TGN51 {437-440} Endocytosis signal; in isoform TGN51 {461-464}

Database Correlations

OMIM 603062 UniProt O43493 Entrez Gene 10618 Kegg hsa:10618

References

UniProt :accession O43493