trans-2-enoyl-CoA reductase, mitochondrial; nuclear receptor-binding factor 1; HsNrbf-1; NRBF-1 (MECR, NBRF1, CGI-63)

Function: 1) catalyzes reduction of trans-2-enoyl-CoA to acyl-CoA with chain length C6-C16 2) mitochondrial synthesis of fatty acids (putative) Acyl-CoA + NADP(+) trans-2,3-dehydroacyl-CoA + NADPH Kinetic parameters - KM=37 uM for trans-2-hexenoyl-CoA - KM=7.1 uM for trans-2-decenoyl-CoA Structure: homodimer Compartment: mitochondria Expression: - expressed in skeletal muscle, heart muscle > placenta, liver, kidney, pancreas > lung

General

mitochondrial protein oxidoreductase

Properties

SIZE: entity length = 373 aa MW = 40 kD COMPARTMENT: mitochondria MOTIF: active site

Database Correlations

OMIM 608205 UniProt Q9BV79 PFAM correlations Entrez Gene 51102 Kegg hsa:51102 ENZYME 1.3.1.38

References

UniProt :accession Q9BV79