transmembrane serine protease 6 (matriptase-2, TMPRSS6)

Function: - specialized role in matrix remodeling processes in liver (putative) Structure: - belongs to the peptidase S1 family - contains 2 CUB domains - contains 3 LDL-receptor class A domains - contains 1 peptidase S1 domain Compartment: membrane Alternative splicing: named isoforms=3 Expression: liver specific

General

glycoprotein transmembrane serine protease

Properties

SIZE: MW = 89 kD entity length = 802 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {47-67} N-glycosylation site {N127} N-glycosylation site {N175} CUB domain {204-327} MOTIF: N-glycosylation site {N207} CUB domain {326-443} MOTIF: cysteine residue {C326} MODIFICATION: cysteine residue {C357} N-glycosylation site {N329} cysteine residue {C357} MODIFICATION: cysteine residue {C326} N-glycosylation site {N424} N-glycosylation site {N444} LDL-receptor class A {448-480} MOTIF: cysteine residue {C449} MODIFICATION: cysteine residue {C461} cysteine residue {C455} MODIFICATION: cysteine residue {C471} cysteine residue {C461} MODIFICATION: cysteine residue {C449} cysteine residue {C465} MODIFICATION: cysteine residue {C480} cysteine residue {C471} MODIFICATION: cysteine residue {C455} cysteine residue {C480} MODIFICATION: cysteine residue {C465} LDL-receptor class A {481-517} MOTIF: cysteine residue {C482} MODIFICATION: cysteine residue {C494} cysteine residue {C488} MODIFICATION: cysteine residue {C507} cysteine residue {C494} MODIFICATION: cysteine residue {C482} cysteine residue {C501} MODIFICATION: cysteine residue {C516} cysteine residue {C507} MODIFICATION: cysteine residue {C488} N-glycosylation site {N509} cysteine residue {C516} MODIFICATION: cysteine residue {C501} LDL-receptor class A {521-558} MOTIF: cysteine residue {C522} MODIFICATION: cysteine residue {C534} cysteine residue {C529} MODIFICATION: cysteine residue {C548} cysteine residue {C534} MODIFICATION: cysteine residue {C522} cysteine residue {C542} MODIFICATION: cysteine residue {C557} cysteine residue {C548} MODIFICATION: cysteine residue {C529} cysteine residue {C557} MODIFICATION: cysteine residue {C542} S1 domain {568-802} MOTIF: cysteine residue {C593} MODIFICATION: cysteine residue {C609} histidine residue {H608} cysteine residue {C609} MODIFICATION: cysteine residue {C593} aspartate residue {D659} cysteine residue {C693} MODIFICATION: cysteine residue {C759} cysteine residue {C724} MODIFICATION: cysteine residue {C738} cysteine residue {C738} MODIFICATION: cysteine residue {C724} cysteine residue {C749} MODIFICATION: cysteine residue {C778} serine residue {S753} cysteine residue {C759} MODIFICATION: cysteine residue {C693} cysteine residue {C778} MODIFICATION: cysteine residue {C749}

Database Correlations

UniProt Q8IU80 PFAM correlations

References

UniProt :accession Q8IU80