transmembrane protease serine 5; spinesin (TMPRSS5)

Function: - may play a role in hearing Structure: - belongs to the peptidase S1 family - contains 1 peptidase S1 domain - contains 1 SRCR domain Compartment: - cell membrane - single-pass type 2 membrane protein (putative) Expression: - brain-specific - predominantly expressed in neurons, in their axons, & at the synapses of motoneurons in the spinal cord Pathology: - defects in TMPRSS5 may be a cause of deafness

General

glycoprotein transmembrane serine protease

Properties

SIZE: entity length = 457 aa MW = 50 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {50-70} SRCR {112-207} MOTIF: cysteine residue {C135} MODIFICATION: cysteine residue {C196} cysteine residue {C148} MODIFICATION: cysteine residue {C206} N-glycosylation site {N163} N-glycosylation site {N170} N-glycosylation site {N195} cysteine residue {C196} MODIFICATION: cysteine residue {C135} cysteine residue {C206} MODIFICATION: cysteine residue {C148} cysteine residue {C209} MODIFICATION: cysteine residue {C328} proteolytic site {217-218} S1 domain {218-453} MOTIF: cysteine residue {C243} MODIFICATION: cysteine residue {C259} histidine residue {H258} cysteine residue {C259} MODIFICATION: cysteine residue {C243} aspartate residue {D308} N-glycosylation site {N319} cysteine residue {C328} MODIFICATION: cysteine residue {C209} cysteine residue {C342} MODIFICATION: cysteine residue {C411} cysteine residue {C374} MODIFICATION: cysteine residue {C390} N-glycosylation site {N375} cysteine residue {C390} MODIFICATION: cysteine residue {C374} cysteine residue {C401} MODIFICATION: cysteine residue {C429} serine residue {S405} cysteine residue {C411} MODIFICATION: cysteine residue {C342} cysteine residue {C429} MODIFICATION: cysteine residue {C401}

Database Correlations

OMIM 606751 UniProt Q9H3S3 Pfam PF00089 Entrez Gene 80975 Kegg hsa:80975

References

UniProt :accession Q9H3S3