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transmembrane protease serine 4; channel-activating protease 2; CAPH2; membrane-type serine protease 2; MT-SP2 (TMPRSS4, UNQ776/PRO1570)
Function:
- probable protease
- seems to be capable of activating ENaC (putative)
Structure:
- belongs to the peptidase S1 family
- contains 1 LDL-receptor class A domain
- contains 1 peptidase S1 domain
- contains 1 SRCR domain
Compartment:
- membrane
- single-pass type 2 membrane protein (putative)
Alternative splicing: named isoforms=3
Expression:
- high levels in pancreatic cancer, gastric cancer, colorectal carcinoma & ampullary cancer
- very weak expression in normal gastrointestinal tract & urogenital tract
General
glycoprotein
transmembrane serine protease
Properties
SIZE: entity length = 437 aa
MW = 48 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {33-53}
LDL-receptor class A {61-93}
MOTIF: cysteine residue {C64}
MODIFICATION: cysteine residue {C83}
cysteine residue {C77}
MODIFICATION: cysteine residue {C92}
cysteine residue {C83}
MODIFICATION: cysteine residue {C64}
cysteine residue {C92}
MODIFICATION: cysteine residue {C77}
SRCR {94-204}
MOTIF: cysteine residue {C127}
MODIFICATION: cysteine residue {C183}
N-glycosylation site {N130}
cysteine residue {C140}
MODIFICATION: cysteine residue {C193}
N-glycosylation site {N178}
cysteine residue {C183}
MODIFICATION: cysteine residue {C127}
cysteine residue {C193}
MODIFICATION: cysteine residue {C140}
cysteine residue {C196}
MODIFICATION: cysteine residue {C310}
proteolytic site {204-205}
S1 domain {205-434}
MOTIF: cysteine residue {C230}
MODIFICATION: cysteine residue {C246}
histidine residue {H245}
cysteine residue {C246}
MODIFICATION: cysteine residue {C230}
aspartate residue {D290}
cysteine residue {C310}
MODIFICATION: cysteine residue {C196}
cysteine residue {C356}
MODIFICATION: cysteine residue {C372}
cysteine residue {C372}
MODIFICATION: cysteine residue {C356}
cysteine residue {C383}
MODIFICATION: cysteine residue {C410}
serine residue {S387}
cysteine residue {C410}
MODIFICATION: cysteine residue {C383}
Database Correlations
OMIM 606565
UniProt Q9NRS4
Pfam PF00089
Entrez Gene 56649
Kegg hsa:56649
References
UniProt :accession Q9NRS4