transmembrane serine protease 13 (mosaic serine protease, membrane-type mosaic serine protease, TMPRSS13, MSP, TMPRSS11)

Structure: - belongs to the peptidase S1 family - contains 1 LDL-receptor class A domain - contains 1 peptidase S1 domain - contains 1 SRCR domain Compartment: membrane Alternative splicing: named isoforms=4 Expression: - isoform 1 & 3 are predominantly expressed in lung, placenta, pancreas, & prostate - isoform 3 is weakly expressed in testis & peripheral blood lymphocytes Polymorphism: - repeat A-S-P-A-[GLQR] is polymorphic, varies from 12-14 repeats

General

glycoprotein transmembrane serine protease

Properties

SIZE: MW = 63 kD entity length = 581 aa COMPARTMENT: cellular membrane MOTIF: alanine-rich region {9-89} MOTIF: alanine residue (SEVERAL) A-S-P-A-[GLQR {9-13} T-P-P-G-R {14-18} A-S-P-A-[GLQR {19-23} A-S-P-A-[GLQR {24-28} T-P-P-G-R {29-33} A-S-P-A-[GLQR. {34-38} A-S-P-A-[GLQR {39-43} A-S-P-A-[GLQR {44-48} T-P-P-G-R {49-53} A-S-P-A-[GLQR {54-58} A-S-P-A-[GLQR {59-63} T-P-P-G-R {64-68} A-S-P-A-[GLQR {69-73} A-S-P-A-[GLQR {74-78} A-S-P-A-[GLQR {79-83} A-S-P-A-[GLQR {84-88} transmembrane domain {161-181} SRCR {190-320} MOTIF: LDL-receptor class A {199-221} cysteine residue {C245} MODIFICATION: cysteine residue {C309} N-glycosylation site {N250} cysteine residue {C258} MODIFICATION: cysteine residue {C312} N-glycosylation site {N287} cysteine residue {C309} MODIFICATION: cysteine residue {C245} cysteine residue {C312} MODIFICATION: cysteine residue {C258} S1 domain {321-554} MOTIF: cysteine residue {C346} MODIFICATION: cysteine residue {C362} histidine residue {H361} cysteine residue {C362} MODIFICATION: cysteine residue {C346} N-glycosylation site {N400} aspartate residue {D409} N-glycosylation site {N440} cysteine residue {C443} MODIFICATION: cysteine residue {C512} cysteine residue {C475} MODIFICATION: cysteine residue {C491} cysteine residue {C491} MODIFICATION: cysteine residue {C475} cysteine residue {C502} MODIFICATION: cysteine residue {C530} serine residue {S506} cysteine residue {C512} MODIFICATION: cysteine residue {C443} cysteine residue {C530} MODIFICATION: cysteine residue {C502}

Database Correlations

UniProt Q9BYE2 Pfam PF00089

References

UniProt :accession Q9BYE2