Transmembrane protein with EGF-like & two follistatin-like domains 2 (transmembrane protein containing epidermal growth factor & follistatin domains, tomoregulin, TR, hyperplastic polyposis protein 1, TMEFF2, HPP1, TENB2, TPEF, UNQ178/PRO204)

Function: 1) may be a novel survival factor for hippocampal & mesencephalic neurons Structure: - N-glycosylated - contains chondroitin sulfate glycosaminoglycans - contains 1 EGF-like domain - contains 2 Kazal-like domains Compartment: membrane Alternative splicing: named isoforms=2 Expression: - highly expressed in the adult & fetal brain, spinal cord & prostate - in brain, expression in all regions of the adult brain except pituitary, highest level in amygdala & corpus callosum - expressed in the pericryptal myofibroblasts & other stromal cells of normal colonic mucosa Pathology: - expressed in prostate carcinoma - more expressed in normal colon than in colorectal cancer

General

glycoprotein membrane protein

Properties

SIZE: MW = 41 kD entity length = 374 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-40} N-glycosylation site {N55} Kazal-type serine protease inhibitor domain {91-135} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+X4} cysteine residue {X+X1} MODIFICATION: cysteine residue {X+X3} cysteine residue {X+X2} MODIFICATION: cysteine residue {X+X5} cysteine residue {X+X3} MODIFICATION: cysteine residue {X+X1} cysteine residue {X+X4} MODIFICATION: cysteine residue {X+0} cysteine residue {X+X5} MODIFICATION: cysteine residue {X+X2} FOR-BINDING-OF: serine protease Kazal-type serine protease inhibitor domain {182-227} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+X4} cysteine residue {X+X1} MODIFICATION: cysteine residue {X+X3} cysteine residue {X+X2} MODIFICATION: cysteine residue {X+X5} cysteine residue {X+X3} MODIFICATION: cysteine residue {X+X1} cysteine residue {X+X4} MODIFICATION: cysteine residue {X+0} cysteine residue {X+X5} MODIFICATION: cysteine residue {X+X2} FOR-BINDING-OF: serine protease N-glycosylation site {N230} EGF domain {261-301} MOTIF: cysteine residue {C265} MODIFICATION: cysteine residue {C278} cysteine residue {C273} MODIFICATION: cysteine residue {C289} cysteine residue {C278} MODIFICATION: cysteine residue {C265} cysteine residue {C289} MODIFICATION: cysteine residue {C273} cysteine residue {C291} MODIFICATION: cysteine residue {C300} cysteine residue {C300} MODIFICATION: cysteine residue {C291} transmembrane domain {321-341}

Database Correlations

OMIM 605734 UniProt Q9UIK5 PFAM correlations

References

UniProt :accession Q9UIK5