Search
transmembrane protein 132A (HSPA5-binding protein 1, TMEM132A, HSPA5BP1, KIAA1583)
Function:
- may play a role in embryonic & postnatal development of the brain
- increased resistance to cell death induced by serum starvation in cultured cells
- regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (putative)
- interacts with HSPA5/GRP78 (putative)
Structure: belongs to the TMEM132 family
Compartment:
- Golgi apparatus membrane
- endoplasmic reticulum membrane
Alternative splicing: named isoforms=4
General
glycoprotein
membrane protein
Properties
SIZE: MW = 110 kD
entity length = 1023 aa
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: signal sequence {1-35}
N-glycosylation site {N280}
Binds to HSPA5/GRP78 {611-916}
Confers cellular localization similar to full-length form {671-1023}
MOTIF: glutamate-rich region {812-835}
MOTIF: glutamate residue (SEVERAL)
transmembrane domain {853-873}
Database Correlations
UniProt Q24JP5
References
UniProt :accession Q24JP5