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transmembrane protease serine 11D; airway trypsin-like protease (TMPRSS11D, HAT)
Function:
1) role in host defense system on mucous membranes
2) preferentially cleaves C-terminal side of arginine residues at the P1 position of certain peptides
3) inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin, soybean trypsin inhibitor
Kinetic parameters:
- optimum pH of 8.6
Structure:
- monomer
- belongs to the peptidase S1 family
- contains 1 peptidase S1 domain
- contains 1 SEA domain
Compartment:
- cell membrane, cleaved & secreted
- single-pass type 2 membrane
Expression:
- expressed in cells of submucosal serous glands of bronchi & trachea
General
glycoprotein
transmembrane serine protease
Properties
SIZE: entity length = 418 aa
MW = 46 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {21-41}
SEA domain {44-164}
MOTIF: N-glycosylation site {N144}
cysteine residue {C173}
MODIFICATION: cysteine residue {C-INTERCHAIN}
S1 domain {187-417}
MOTIF: cysteine residue {C212}
MODIFICATION: cysteine residue {C228}
histidine residue {H227}
cysteine residue {C228}
MODIFICATION: cysteine residue {C212}
aspartate residue {D272}
cysteine residue {C337}
MODIFICATION: cysteine residue {C353}
cysteine residue {C353}
MODIFICATION: cysteine residue {C337}
cysteine residue {C364}
MODIFICATION: cysteine residue {C393}
serine residue {S368}
cysteine residue {C393}
MODIFICATION: cysteine residue {C364}
Database Correlations
OMIM 605369
UniProt O60235
PFAM correlations
Entrez Gene 9407
Kegg hsa:9407
References
UniProt :accession O60235