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transmembrane glycoprotein NMB (transmembrane glycoprotein HGFIN, GPNMB, HGFIN, NMB, UNQ1725/PRO9925)
Function:
- may be a melanogenic enzyme
Structure:
- contains 1 PKD domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression: not restricted to the melanocytic lineage
Pathology:
- expression in poorly metastatic melanoma cell lines
- no expression in highly metastatic melanoma cell lines
General
glycoprotein
membrane protein
Properties
SIZE: MW = 64 kD
entity length = 572 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
Cell attachment site {64-66}
N-glycosylation site {N93}
N-glycosylation site {N134}
N-glycosylation site {N146}
N-glycosylation site {N200}
PKD {240-327}
MOTIF: N-glycosylation site {N249}
N-glycosylation site {N275}
N-glycosylation site {N296}
N-glycosylation site {N300}
N-glycosylation site {N306}
N-glycosylation site {N312}
proline-rich region
SITE: 320-332
MOTIF: proline residue (SEVERAL)
N-glycosylation site {N459}
N-glycosylation site {N467}
transmembrane domain {487-507}
Database Correlations
OMIM 604368
UniProt Q14956
Pfam PF00801
References
UniProt :accession Q14956