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transmembrane 7 superfamily member 2 (delta(14)-sterol reductase, C-14 sterol reductase, sterol C14-reductase, delta-14-SR, another new gene 1 protein, sterol reductase SR-1, TM7SF2, ANG1)
Function:
- conversion of lanosterol to cholesterol
Compartment: endoplasmic reticulum
Alternative splicing: named isoforms=2
Expression:
- expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, testis
- not expressed in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes
General
oxidoreductase
transmembrane 7 protein
Properties
SIZE: MW = 46 kD
entity length = 418 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {13-35}
transmembrane domain {62-81}
transmembrane domain {102-124}
transmembrane domain {129-148}
transmembrane domain {255-277}
transmembrane domain {287-304}
transmembrane domain {355-377}
Database Correlations
OMIM 603414
UniProt O76062
Pfam PF01222
ENZYME 1.3.1.70
References
UniProt :accession O76062