tetraspanin-3; Tspan-3; tetraspanin TM4-A; transmembrane 4 superfamily member 8 (TSPAN3, TM4SF8)

Function: - regulates proliferation & migration of oligodendrocytes, a process essential for normal myelination & repair (putative) - interacts with claudin-11/CLDN11 & integrins Structure: belongs to the tetraspanin (TM4SF) family Compartment: membrane (probable)

General

glycoprotein tetraspanin (transmembrane-4-superprotein)

Properties

SIZE: entity length = 253 aa MW = 28 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-11} transmembrane domain {12-32} exoplasmic loop {33-50} transmembrane domain {51-71} cytoplasmic loop {72-85} transmembrane domain {86-106} exoplasmic loop {107-212} MOTIF: N-glycosylation site {N127} N-glycosylation site {N152} N-glycosylation site {N167} N-glycosylation site {N183} transmembrane domain {213-233} cytoplasmic domain {234-253}

Database Correlations

OMIM 613134 UniProt O60637 Pfam PF00335 Entrez Gene 10099

References

UniProt :accession O60637