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transmembrane 4 L6 family member 4; intestine & liver tetraspan membrane protein; IL-TMP (TM4SF4 ILTMP)
Function:
- regulates adhesive & proliferative status of intestinal epithelial cells
- can mediate density-dependent cell proliferation
Structure:
- N-glycosylated; glycosylation is required for the growth inhibitory effect
- belongs to the L6 tetraspanin family
Compartment: membrane
Expression: jejunum & liver
General
glycoprotein
tetraspanin (transmembrane-4-superprotein)
Properties
SIZE: entity length = 202 aa
MW = 21 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-9}
transmembrane domain {10-30}
exoplasmic loop {31-45}
transmembrane domain {46-66}
cytoplasmic loop {67-93}
transmembrane domain {94-114}
exoplasmic loop {115-158}
MOTIF: N-glycosylation site {N124}
N-glycosylation site {N156}
transmembrane domain {159-179}
cytoplasmic domain {180-202}
Database Correlations
OMIM 606567
UniProt P48230
Pfam PF05805
Entrez Gene 7104
Kegg hsa:7104
References
UniProt :accession P48230