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transient receptor potential cation channel subfamily V member 4 (TrpV4, vanilloid receptor-like 2, VRL-2, osm-9-like TRP channel 4, OTRPC4, vanilloid receptor-related osmotically-activated channel, VR-OAC, transient receptor potential protein 12, TRP12, VRL2, VROAC)
Function:
1) non-selective Ca+2 channel
2) involved in osmotic sensitivity & mechanosensitivity
3) activation by hypotonicity within the physiological range exhibits an outward rectification
4) activated by low pH, citrate, phorbol esters
5) increased intracellular Ca+2 potentiates currents
6) channel activity regulated by calmodulin
7) interacts with calmodulin, Map7, Src family Tyr kinases LYN, SRC, FYN, HCK, LCK, YES
Compartment: membrane
Alternative splicing: named isoforms=3
General
Ca+2 channel
glycoprotein
transient receptor potential cation channel subfamily V (TRPV)
transmembrane 6 protein
Properties
SIZE: MW = 98 kD
entity length = 871 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-465}
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 237-266
Tyr phosphorylation site {Y253}
ankyrin repeat
NAME: ankyrin repeat
SITE: 284-313
ankyrin repeat
NAME: ankyrin repeat
SITE: 369-398
transmembrane domain {466-486}
exoplasmic loop {487-508}
transmembrane domain {509-529}
cytoplasmic loop {530-550}
transmembrane domain {551-571}
exoplasmic loop {572-572}
transmembrane domain {573-593}
cytoplasmic loop {594-616}
transmembrane domain {617-637}
exoplasmic loop {638-690}
transmembrane domain {691-711}
cytoplasmic domain {712-871}
MOTIF: calmodulin binding site
SITE: 812-831
FOR-BINDING-OF: calmodulin
ION-PERMEABILITY: Ca+2
Database Correlations
OMIM 605427
MORBIDMAP 605427
UniProt Q9HBA0
PFAM correlations
References
UniProt :accession Q9HBA0