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transient receptor potential cation channel subfamily V member 3 (TrpV3, vanilloid receptor-like 3, VRL-3)
Function:
1) receptor-activated non-selective Ca+2 channel
2) activated by innocuous (warm) temperatures
3) shows increased response at noxious temperatures greater than 39 degrees Celsius
4) activation exhibits an outward rectification
5) may associate with TRPV1 & may modulate its activity
6) may form a heteromeric channel with TRPV
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- expressed in CNS, dorsal root ganglion,
- widely expressed at low levels
General
Ca+2 channel
glycoprotein
phosphoprotein
transient receptor potential cation channel subfamily V (TRPV)
transmembrane 6 protein
Properties
SIZE: MW = 91 kD
entity length = 790 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-439}
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 214-243
ankyrin repeat
NAME: ankyrin repeat
SITE: 261-291
ankyrin repeat
NAME: ankyrin repeat
SITE: 340-369
transmembrane domain {440-460}
exoplasmic loop {461-487}
transmembrane domain {488-508}
cytoplasmic loop {509-523}
transmembrane domain {524-544}
exoplasmic loop {545-545}
transmembrane domain {546-566}
cytoplasmic loop {567-589}
transmembrane domain {590-610}
exoplasmic loop {611-649}
transmembrane domain {650-670}
cytoplasmic domain {671-790}
ION-PERMEABILITY: Ca+2
Database Correlations
OMIM 607066
UniProt Q8NET8
PFAM correlations
References
UniProt :accession Q8NET8