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transient receptor potential cation channel subfamily V member 2 (TrpV2, osm-9-like TRP channel 2, OTRPC2, vanilloid receptor-like protein 1, VRL-1, VRL)
Function:
1) non-selective Ca+2 channel with an outward rectification
2) regulated by IGF1, PDGF, neuropeptide head activator
3) may transduce physical stimuli in mast cells
4) activated by temperatures higher than 52 degrees Celsius
4) NOT activated by vanilloids or acidic pH
5) interacts with PRKAR2A or PRKAR2B, ACBD3, RGA
6) phosphorylated by PKA
Structure:
- homotetramer (probable)
- N-glycosylated
Compartment:
- cell membrane, cytoplasm, translocates from cytoplasm to plasma membrane upon ligand stimulation
General
Ca+2 channel
glycoprotein
transient receptor potential cation channel subfamily V (TRPV)
transmembrane 6 protein
Properties
SIZE: MW = 86 kD
entity length = 764 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-390}
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 162-191
ankyrin repeat
NAME: ankyrin repeat
SITE: 208-237
ankyrin repeat
NAME: ankyrin repeat
SITE: 293-323
transmembrane domain {391-411}
exoplasmic loop {412-434}
transmembrane domain {435-455}
cytoplasmic loop {456-471}
transmembrane domain {472-492}
exoplasmic loop {493-493}
transmembrane domain {494-514}
cytoplasmic loop {515-537}
transmembrane domain {538-558}
exoplasmic loop {559-621}
transmembrane domain {622-642}
cytoplasmic domain {643-764}
ION-PERMEABILITY: Ca+2
Database Correlations
OMIM 606676
UniProt Q9Y5S1
PFAM correlations
References
UniProt :accession Q9Y5S1