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transient receptor potential cation channel subfamily M member 3 (TrpM3, long transient receptor potential channel 3, LTrpC3, melastatin-2, MLSN2, KIAA1616)
Function:
1) constitutive Ca+2 channel
2) activity increased by
a) decreased extracellular osmolarity
b) muscarinic receptor activation
Compartment: membrane
Alternative splicing: named isoforms=10
Expression:
- expressed kidney > brain, testis, ovary, pancreas, spinal cord
- in the kidney, expressed predominantly in collecting tubular epithelium in the renal medulla, medullary rays & periglomerular regions
- in the brain, expression greatest in cerebellum, choroid plexus, locus coeruleus, posterior thalamus, substantia nigra
Pathology:
- down-regulated in renal tumors compared to normal kidney
General
Ca+2 channel
Na+ channel
transient receptor potential cation channel subfamily M (TRPM)
transmembrane 7 protein
Properties
SIZE: MW = 198 kD
entity length = 1732 aa
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-3}
transmembrane domain {4-24}
cytoplasmic loop {25-794}
transmembrane domain {795-815}
exoplasmic loop {816-897}
transmembrane domain {898-918}
cytoplasmic loop {919-964}
transmembrane domain {965-985}
exoplasmic loop {986-995}
transmembrane domain {996-1016}
cytoplasmic loop {1017-1028}
transmembrane domain {1029-1049}
exoplasmic loop {1050-1116}
transmembrane domain {1117-1137}
cytoplasmic domain {1138-1732}
MOTIF: coiled coil {1241-1301}
ION-PERMEABILITY: Ca+2
Database Correlations
UniProt Q9HCF6
Pfam PF00520
References
UniProt :accession Q9HCF6