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transient receptor potential cation channel subfamily M member 1 (long transient receptor potential channel 1, LTrpC1, melastatin-1, TRPM1, LTRPC1, MLSN, MLSN1)
Function:
- Ca+2 channel
- may act as a spontaneously active, Ca+2-permeable plasma membrane channel
- mediates cation influx in HEK293 cells
- may play a role in suppression of metastasis
Structure:
- belongs to the transient receptor family, LTrpC subfamily
Compartment: cell membrane
Alternative splicing: named isoforms=4
Expression:
- highly expressed in benign melanocytic nevi
- expressed in melanocytes & pigmented metastatic melanoma cell lines
- in melanocytes expression appears to be regulated at the level of transcription & mRNA processing
- up-regulated by hexamethylene bisacetamide (HBMA)
Pathology:
- diffusely expressed in various in situ melanomas, but not detected in melanoma metastases
General
Ca+2 channel
phosphoprotein
receptor
transmembrane 9 protein
Properties
SIZE: entity length = 1603 aa
MW = 182 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-524}
MOTIF: Thr phosphorylation site {T423}
Thr phosphorylation site {T424}
transmembrane domain {525-545}
cytoplasmic loop {546-745}
transmembrane domain {746-766}
exoplasmic loop {767-830}
transmembrane domain {831-851}
cytoplasmic loop {852-852}
transmembrane domain {853-873}
exoplasmic loop {874-897}
transmembrane domain {898-918}
cytoplasmic loop {919-928}
transmembrane domain {929-949}
exoplasmic loop {950-961}
transmembrane domain {962-982}
cytoplasmic loop {983-1054}
transmembrane domain {1055-1075}
exoplasmic loop {1076-1105}
transmembrane domain {1106-1126}
cytoplasmic domain {1127-1603}
MOTIF: coiled coil {1179-1240}
ION-PERMEABILITY: Ca+2
Database Correlations
OMIM 603576
UniProt Q7Z4N2
Pfam PF00520
References
UniProt :accession Q7Z4N2