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transient receptor potential cation channel subfamily A member 1 (ankyrin-like with transmembrane domains protein 1, transformation sensitive-protein p120, TRPA1, ANKTM1)
Function:
1) receptor-activated non-selective cation channel involved
2) detection of sensations such as cold, pain or sounds perception
3) cold nociception, activated by cold temperature below 17 degrees Celsius
4) pain sensation triggered by mustard oil or capsaicin
5) ionotropic cannabinoid receptor
6) component for the mechanosensitive transduction channel of hair cells in inner ear (putative)
7) uses phosphatidylinositol second messenger system (putative)
8) inhibited by ruthenium red
Structure:
- belongs to the transient receptor family
- contains 15 ANK repeats
Compartment: membrane
Expression: expressed at very low level
Pathology:
- may be expressed at a higher level in liposarcoma cells
General
cell surface receptor
ion channel
transmembrane 6 protein
Properties
SIZE: MW = 127 kD
entity length = 1119 aa
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-719}
MOTIF: ankyrin repeat
NAME: ankyrin repeat (15)
SITE: 62-609
transmembrane domain {720-740}
exoplasmic loop {741-772}
MOTIF: N-glycosylation site {N747}
N-glycosylation site {N753}
transmembrane domain {773-793}
cytoplasmic loop {794-805}
transmembrane domain {806-826}
exoplasmic loop {827-829}
transmembrane domain {830-850}
cytoplasmic loop {851-873}
transmembrane domain {874-894}
exoplasmic loop {895-940}
transmembrane domain {941-961}
cytoplasmic domain {962-1119}
Database Correlations
OMIM 604775
UniProt O75762
PFAM correlations
References
- UniProt :accession O75762
- Protein Spotlight; Note: The power behind pain -
Issue 82 of may 2007
http://www.expasy.org/spotlight/back_issues/sptlt082.shtml