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transglutaminase-3 (tranglutaminase-E, E3, TGM3)
Function:
- catalyzes the cross-linking of proteins & the conjugation of polyamines to proteins
- responsible for the later stages of cell envelope formation in the epidermis & the hair follicle
protein glutamine + alkylamine
protein N(5)-alkylglutamine + NH3
Cofactor: binds 1 Ca+2 per subunit (putative)
Structure:
- consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide activated by proteolytic processing
- belongs to the transglutaminase superfamily transglutaminase family82 1993
General
multisubunit protein
regulatory molecule
transglutaminase (protein-glutamine:amine gamma-glutamyltransferase)
Properties
SIZE: entity length = 693 aa
MW = 77 kD
STATE: Inactive
MOTIF: cysteine residue {C273}
histidine residue {H331}
aspartate residue {D354}
Ca+2-binding site
SITE: 394-394
Ca+2-binding site
SITE: 396-396
Ca+2-binding site
SITE: 444-444
Ca+2-binding site
SITE: 449-449
Database Correlations
OMIM 600238
UniProt Q08188
PFAM correlations
Entrez Gene 7053
Kegg hsa:7053
ENZYME 2.3.2.13
References
- Kim et al J Biol Chem 268:126
- NIEHS SNPs
http://egp.gs.washington.edu/data/tgm3/
- UniProt :accession Q08188