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transfusion-associated viral infection

Etiology: 1) HIV: 1 per 3.1 million units 2) hepatitis C: 1 per 230,000 units 3) CMV [4] Risks for tissue donation is higher: about 1 per 42,000-55,000 Management: - CMV transmission: - prevention: leukoreduction, CMV-negative donor - treatment: ganciclovir or foscarnet [4] - see blood transfusion reaction

Related

blood donation blood transfusion

General

transfusion-associated infection viral infection

References

  1. Journal Watch 24(18):147, 2004 Stramer SL, Glynn SA, Kleinman SH, Strong DM, Sally C, Wright DJ, Dodd RY, Busch MP; National Heart, Lung, and Blood Institute Nucleic Acid Test Study Group. Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid-amplification testing. N Engl J Med. 2004 Aug 19;351(8):760-8. PMID: 15317889
  2. Zou S, Dodd RY, Stramer SL, Strong DM; Tissue Safety Study Group. Probability of viremia with HBV, HCV, HIV, and HTLV among tissue donors in the United States. N Engl J Med. 2004 Aug 19;351(8):751-9. PMID: 15317888
  3. Goodman JL. (No abstract) The safety and availability of blood and tissues--progress and challenges. N Engl J Med. 2004 Aug 19;351(8):819-22. No abstract available. PMID: 15317896
  4. Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012