transforming growth factor beta regulator 1 (nuclear interactor of ARF & Mdm2, TBRG1, NIAM)

Function: - acts as a growth inhibitor - can activate TP53/p53, causes G1 arrest & collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis - redistributes CDKN2A into the nucleoplasm - role in maintaining chromosomal stability - interacts with CDKN2A & MDM2 - ubiquitination mediated by MDM2 leads to proteasomal degradation Structure: - belongs to the TBRG1 family - contains 1 FY-rich C-terminal domain - contains 1 FY-rich N-terminal domain Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - widely expressed at low levels in most tissues - highest levels in pancreas, lung & liver Pathology: - expression is decreased in primary tumors including lung cancer, hepatocellular carcinoma, breast cancer, pancreatic cancer, renal cell carcinomas, chronic lymphocytic leukemia & diffuse large B-cell lymphoma

Properties

SIZE: MW = 45 kD entity length = 411 aa COMPARTMENT: cell nucleus MOTIF: lysine-rich region {134-161} MOTIF: lysine residue (SEVERAL) FY-rich N-terminal {187-239} FY-rich C-terminal {242-326}

Database Correlations

UniProt Q3YBR2 PFAM correlations

References

UniProt :accession Q3YBR2