transforming growth factor-beta receptor-associated protein 1; TGF-beta receptor-associated protein 1; TRAP-1; TRAP1 (TGFBRAP1)

Function: - plays a role in the TGF-beta/activin signaling pathway - associates with inactive heteromeric TGF-beta & activin receptor complexes, mainly through the type II receptor, & is released upon activation of signaling - may recruit SMAD4 to the vicinity of the receptor complex & facilitate its interaction with receptor-regulated smads, such as SMAD2 - interacts with TGFBR2 & ACVR2B; in the absence of ligand stimulation - interacts with TGFBR1, ACVRL1, BMPR1A & ACVR1B; in the absence of ligand stimulation - interacts with SMAD4; the interaction seems to be mutually exclusive with the interaction of SMAD4 & phosphorylated SMAD2 - may interact with ALOX5 Structure: belongs to the TRAP1 family Compartment: - cytoplasm - colocalizes with TGF-beta receptors in the absence of signaling

Properties

SIZE: entity length = 860 aa MW = 97 kD COMPARTMENT: cytoplasm MOTIF: ligand-binding site

Database Correlations

UniProt Q8WUH2 Kegg hsa:9392

References

UniProt :accession Q8WUH2