transforming acidic coiled-coil-containing protein 2 (anti Zuai-1, AZU-1, TACC2)

Function: 1) role in organizing centrosomal microtubules (putative) 2) tumor suppressor protein (putative) 3) tumor progression marker (putative) 4) interacts with microtubules Structure: 1) belongs to the TACC family 2) contains 1 SPAZ domain (Ser/Pro-rich AZU-1 domain) Compartment: nucleus, centrosome Alternative splicing: named isoforms=3

General

cytoskeletal protein phosphoprotein

Properties

SIZE: MW = 112 kD entity length = 1026 aa COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 43-51 MOTIF: proline residue (SEVERAL) PAZ domain {393-481} lysine-rich region {498-501} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S590} coiled coil {753-781} coiled coil {824-1025}

Database Correlations

OMIM 605302 UniProt O95359 Pfam PF05010

References

UniProt :accession O95359