transducin-like enhancer protein 6 (TLE6)

Function: - transcriptional corepressor that binds to a number of transcription factors - inhibits transcriptional activation mediated by CTNNB1 & TCF family members in Wnt signaling - effects of full-length TLE family members may be modulated by association with dominant-negative AES - homooligomer & heterooligomer with other family members Structure: - belongs to the WD repeat Groucho/TLE family - contains 7 WD repeats Compartment: nucleus

General

transcriptional silencer (transcriptional repressor) transducin-like enhancer protein (ESG)

Properties

SIZE: MW = 50 kD entity length = 449 aa COMPARTMENT: cell nucleus MOTIF: WD repeat {161-199} WD repeat {209-249} WD repeat {254-293} WD repeat {296-333} WD repeat {335-374} WD repeat {376-415} WD repeat {417-448}

Database Correlations

UniProt Q9H808 Pfam PF00400

References

UniProt :accession Q9H808