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transducin-like enhancer protein 4 (TLE4, KIAA1261)
Function:
- transcriptional corepressor that binds to a number of transcription factors
- inhibits transcriptional activation mediated by PAX5, CTNNB1 & TCF family members in Wnt signaling
- effects of full-length TLE family members may be modulated by association with dominant-negative AES
- homooligomer & heterooligomer with other family members
- binds PAX5, LEF1, TCF7, TCF7L1 & TCF7L2
Structure:
- belongs to the WD repeat groucho/TLE family
- contains 7 WD repeats
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- expressed in all tissues examined, including brain & skeletal muscle
General
transducin-like enhancer protein (ESG)
Properties
SIZE: entity length = 773 aa
MW = 84 kD
COMPARTMENT: cell nucleus
MOTIF: glutamine-rich region {1-137}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 138-205
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S206}
CCN {207-274}
MOTIF: Ser phosphorylation site {S208}
Tyr phosphorylation site {Y243}
Ser phosphorylation site {S245}
Ser phosphorylation site {S250}
Ser phosphorylation site {S265}
Ser phosphorylation site {S292}
Ser phosphorylation site {S305}
alanine-rich region {405-415}
MOTIF: alanine residue (SEVERAL)
WD repeat {485-523}
WD repeat {531-570}
WD repeat {575-614}
WD repeat {617-656}
WD repeat {658-697}
WD repeat {699-738}
WD repeat {740-773}
Database Correlations
OMIM 605132
UniProt Q04727
PFAM correlations
Entrez Gene 7091
Kegg hsa:7091
References
UniProt :accession Q04727