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transducin-like enhancer protein 3; enhancer of split groucho-like protein 3; ESG3 (TLE3 KIAA1547)
Function:
- transcriptional corepressor that binds to a number of transcription factors
- inhibits transcriptional activation mediated by CTNNB1 & TCF family members in Wnt signaling
- effects of full-length TLE family members may be modulated by association with dominant-negative AES (putative)
- homooligomer & heterooligomer with other family members
- binds LEF1, TCF7, TCF7L1 & TCF7L2 (putative)
- binds FOXA2
Structure:
- belongs to the WD repeat groucho/TLE family
- contains 7 WD repeats
Compartment: nucleus
Alternative splicing: named isoforms=4
Expression:
- expressed in placenta & lung
General
transducin-like enhancer protein (ESG)
Properties
SIZE: entity length = 772 aa
MW = 83 kD
COMPARTMENT: cell nucleus
MOTIF: glutamine-rich region {1-131}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 132-198
MOTIF: proline residue (SEVERAL)
CCN {199-268}
MOTIF: Ser phosphorylation site {S201}
Ser phosphorylation site {S203}
Ser phosphorylation site {S205}
Ser phosphorylation site {S207}
Ser phosphorylation site {S217}
nuclear translocation signal {225-228}
Ser phosphorylation site {S240}
Ser phosphorylation site {S245}
Thr phosphorylation site {T259}
Ser phosphorylation site {S263}
Ser phosphorylation site {S267}
serine-rich region {269-451}
MOTIF: serine residue (SEVERAL)
Thr phosphorylation site {T285}
Ser phosphorylation site {S286}
Ser phosphorylation site {S289}
Ser phosphorylation site {S292}
Ser phosphorylation site {S299}
Ser phosphorylation site {S311}
Thr phosphorylation site {T312}
Ser phosphorylation site {S317}
Thr phosphorylation site {T319}
Thr phosphorylation site {T321}
Thr phosphorylation site {T328}
Thr phosphorylation site {T334}
alanine-rich region {401-409}
MOTIF: alanine residue (SEVERAL)
Ser phosphorylation site {S413}
WD repeat {484-522}
WD repeat {530-569}
WD repeat {574-613}
WD repeat {616-655}
WD repeat {657-696}
WD repeat {698-737}
WD repeat {739-771}
Database Correlations
OMIM 600190
UniProt Q04726
PFAM correlations
Entrez Gene 7090
Kegg hsa:7090
References
UniProt :accession Q04726