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transducin-like enhancer protein 2; enhancer of split groucho-like protein 2; ESG2 (TLE2)
Function:
- transcriptional corepressor that binds to a number of transcription factors
- inhibits transcriptional activation mediated by CTNNB1 & TCF family members in Wnt signaling
- effects of full-length TLE family members may be modulated by association with dominant-negative AES (putative)
- homooligomer & heterooligomer with other family members
- binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 & HES5
Structure:
- belongs to the WD repeat groucho/TLE family
- contains 6 WD repeats
Compartment: nucleus
Expression:
- expressed in all tissues examined, including heart, brain, & muscle
General
transducin-like enhancer protein (ESG)
Properties
SIZE: entity length = 743 aa
MW = 80 kD
COMPARTMENT: cell nucleus
MOTIF: glutamine-rich region {1-133}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 134-194
MOTIF: proline residue (SEVERAL)
CCN {195-256}
MOTIF: nuclear translocation signal {214-217}
Ser phosphorylation site {S228}
Ser phosphorylation site {S249}
Thr phosphorylation site {T253}
serine-rich region {257-398}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S271}
Ser phosphorylation site {S281}
WD repeat {455-493}
WD repeat {501-540}
WD repeat {545-584}
WD repeat {587-626}
WD repeat {669-708}
WD repeat {710-742}
Database Correlations
OMIM 601041
UniProt Q04725
PFAM correlations
Entrez Gene 7089
Kegg hsa:7089
References
UniProt :accession Q04725