transcription termination factor 1 (TTF-1, RNA polymerase I termination factor, TTF1)

Function: 1) multifunctional nucleolar protein 2) terminates ribosomal gene transcription 3) mediates replication fork arrest 4) regulates RNA polymerase 1 transcription on chromatin 5) role in rDNA regulation, role in both activation & silencing of rDNA transcription 6) interaction with TIP5 recovers DNA-binding activity 7) N-terminal region inhibits DNA-binding via its interaction with the C-terminal region Structure: 1) oligomer, enables TTF1 to interact simultaneously with 2 separate DNA fragments 2) contains 2 Myb DNA-binding domains Compartment: nucleus, nucleolus

General

DNA-binding protein phosphoprotein

Properties

SIZE: MW = 101 kD entity length = 886 aa COMPARTMENT: cell nucleus MOTIF: lysine-rich region {216-225} MOTIF: lysine residue (SEVERAL) lysine-rich region {272-282} MOTIF: lysine residue (SEVERAL) lysine-rich region {329-338} MOTIF: lysine residue (SEVERAL) DNA-binding motif SITE: 612-661 DNA-binding motif SITE: 661-745 Ser phosphorylation site {S872}

Database Correlations

OMIM 600777 UniProt Q15361 Pfam PF00249

References

UniProt :accession Q15361