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transcription regulator protein BACH1; BTB & CNC homolog 1; HA2303 (BACH1)
Function:
- transcriptional regulator that acts as repressor or activator
- binds, in-vitro, to NF-E2 binding sites
- role in coordinating transcription activation & transcriptional repression by MAFK
Structure:
- belongs to the bZIP family, CNC subfamily
- contains 1 BTB/POZ domain
- contains 1 bZIP domain
Compartment: nucleus (putative)
Related
Fanconi anemia group J protein; protein FACJ; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1-interacting protein 1 (BRIP1, BACH1, FANCJ)
General
basic leucine zipper (bZIP) family protein
DNA-binding protein
phosphoprotein
Properties
SIZE: entity length = 736 aa
MW = 82 kD
COMPARTMENT: cell nucleus
MOTIF: BTB domain {34-100}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S196}
Tyr phosphorylation site {Y321}
Ser phosphorylation site {S322}
Thr phosphorylation site {T328}
Ser phosphorylation site {S445}
DNA-binding motif
SITE: 562-577
leucine zipper
SITE: 585-607
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 602751
UniProt O14867
PFAM correlations
Entrez Gene 571
Kegg hsa:571
References
UniProt :accession O14867