transcription initiation factor TFIID subunit 8; protein taube nuss; TBP-associated factor 43 kDa; TBP-associated factor 8; transcription initiation factor TFIID 43 kD subunit; TAFII-43; TAFII43; hTAFII43 (TAF8, TAFII43, TBN)

Function: - transcription factor TFIID subunit - plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. - required for the integration of TAF10 in the TAF complex - may be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (putative) - interacts with TBP, TAF1, TAF6, TAF10, TAF11 & TAF13 - component also of a small TAF complex - forms a heterodimer with TAF10 Structure: - interaction with TAF10 is mediated mainly via its histone fold domain while interaction with SUPT7L is via its C-terminal region - ectopic expression of the histone fold domain acts as a dominant-negative mutant resulting in differentiation inhibition - belongs to the TAF8 family - contains 1 histone-fold domain Compartment: - nucleus, cytoplasm - localized in the cytoplasm & transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell (putative) Alternative splicing: named isoforms=4 Expression: induced with triglyceride accumulation Miscellaneous: 'Taube nuss' means 'empty nut' in German

General

nuclear protein phosphoprotein protein subunit

Properties

SIZE: entity length = 310 aa MW = 34 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Histone-fold {35-102} Thr phosphorylation site {T130} nuclear translocation signal {294-307}

Database Correlations

OMIM 609514 UniProt Q7Z7C8 PFAM correlations Entrez Gene 129685 Kegg hsa:129685

References

UniProt :accession Q7Z7C8