transcription initiation factor TFIID subunit 7-like (transcription initiation factor TFIID 50 kD subunit, TATA box-binding protein-associated factor 50 kD, RNA polymerase 2 TBP-associated factor subunit Q, cancer/testis antigen 40, CT40, TAF7L, TAF2Q)

Function: - spermatogensis-specific component of DNA-binding general transcription factor complex TFIID (putative) - TAF7L may replace TAF7 in a spermatogenensis-specific form of TFIID - role in spermatogenesis (putative) TAF7L may replace TAF7 in a spermatogenensis-specific form of TFIID - interacts with TBP in a sub-population of cells (pachytene & haploid round spermatids), developmentally regulated through differential intracellular localization of the two proteins - interacts with TAF1 (putative) Structure: belongs to the TAF7 family Compartment: - nucleus (putative), cytoplasm - cytoplasmic in spermatogonia & early spermatocytes (preleptotene, leptotene, & zygotene) - translocates into the nuclei of pachytene spermatocytes & round spermatids (putative) Alternative splicing: named isoforms=3 Expression: testis-specific

General

nuclear protein testis-specific protein

Properties

SIZE: entity length = 462 aa MW = 53 kD COMPARTMENT: cell nucleus MOTIF: glutamate-rich region {336-377} MOTIF: glutamate residue (SEVERAL) coiled coil {342-462}

Database Correlations

OMIM 300314 UniProt Q5H9L4 Pfam PF04658

References

UniProt :accession Q5H9L4