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transcription factor YY2 (Yin & yang 2, YY-2, zinc finger protein 631, YY2, ZNF631)
Function:
- multifunctional transcription factor
- may exhibit positive & negative control on a large number of genes
- may antagonize YY1 & function in development & differentiation
Structure:
- belongs to the YY transcription factor family
- contains 4 C2H2-type Zn+2 fingers
Compartment: nucleus (probable)
Expression:
- expressed in kidney, liver, spleen & testis
- not expressed in colon
Miscellaneous:
- gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals
- encoded by a single exon found in an intron of the gene MBTPS2
General
C2H2 type zinc finger protein
transcription factor (TF)
Properties
SIZE: entity length = 372 aa
MW = 41 kD
COMPARTMENT: cell nucleus
MOTIF: Mediates transcriptional activation {32-102}
silencer element
SITE: 237-372
MOTIF: Zn finger C2H2-type
SITE: 254-278
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 283-305
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 311-335
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 341-365
EFFECTOR-BOUND: Zn+2
Database Correlations
UniProt O15391
Pfam PF00096
Kegg hsa:4042
References
UniProt :accession O15391