transcription factor TFIIIB component B'' homolog (transcription factor IIIB 150, TFIIIB150, transcription factor-like nuclear regulator, BDP1, KIAA1241, KIAA1689, TFNR)

Function: - general activator of RNA polymerase 3 transcription - requires for transcription from all 3 types of RNA polymerase 3 promoters - requires for transcription of genes with internal promoter elements & with promoter elements upstream of the initiation site - component of TFIIIB complex. - interacts with BRF1; this interaction diminishes during mitosis resulting in release of BDP1 from chromosomal templates - component of TFIIIC complex - interacts with ZBTB43 - phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin & suppression of RNA polymerase 3 transcription - phosphorylated upon DNA damage, probably by ATM or ATR Structure: contains 1 Myb-like domain Compartment: nucleus Alternative splicing: named isoforms=8 Expression: - isoform 2 is highly expressed in cerebellum - induced by epstein-Barr virus (EBV) resulting in the stimulation of the EBV EBER genes

General

nuclear protein phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 2624 aa MW = 294 kD COMPARTMENT: cell nucleus MOTIF: ZBTB43 interaction {1-299} MOTIF: serine-rich region {84-119} MOTIF: serine residue (SEVERAL) coiled coil {144-177} Myb-like {295-345} phosphorylation by CSNK2A1 {355-470} repeat {823-1327} MOTIF: consensus repeat {823-877} consensus repeat {878-932} consensus repeat {933-987} consensus repeat {988-1040} consensus repeat {1041-1094} coiled coil {1078-1103} consensus repeat {1095-1148} consensus repeat {1149-1203} consensus repeat {1204-1257} coiled coil {1223-1284} consensus repeat {1258-1327} Ser phosphorylation site {S2196}

Database Correlations

OMIM 607012 UniProt A6H8Y1 Pfam PF00249

References

UniProt :accession A6H8Y1