transcription factor SPT20 homolog; p38-interacting protein; p38IP (SUPT20H, C13orf19, FAM48A, FP757)

Function: - required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 &/or MAPK14) activation during gastrulation - required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase & independently of regulation of transcription by FGF signaling & snail (putative) - required for starvation-induced ATG9A trafficking during autophagy - interacts with MAPK14 - interacts with ATG9A Structure: belongs to the SPT20 family Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - highly expressed in testis - moderately in brain & pituitary gland - expressed in several fetal tissues, including lung, brain, thymus & kidney Pathology: - expression is down-regulated in prostate cancer

General

phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 779 aa MW = 86 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S519} glutamine-rich region {636-754} MOTIF: glutamine residue (SEVERAL)

Database Correlations

OMIM 613417 UniProt Q8NEM7 Pfam PF12090 Entrez Gene 55578 Kegg hsa:55578

References

UniProt :accession Q8NEM7