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transcription factor Sp9 (SP9)

Function: - transcription factor - plays a role in limb development - positively regulates FGF8 expression in the apical ectodermal ridge (AER) & contributes to limb outgrowth in embryos (putative) Structure: - belongs to the Sp1 C2H2-type Zn+2-finger protein family - contains 3 C2H2-type Zn+2 fingers Compartment: nucleus (probable)

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: entity length = 484 aa MW = 49 kD COMPARTMENT: cell nucleus MOTIF: serine-rich region {53-56} MOTIF: serine residue (SEVERAL) alanine-rich region {113-120} MOTIF: alanine residue (SEVERAL) alanine-rich region {241-244} MOTIF: alanine residue (SEVERAL) alanine-rich region {272-299} MOTIF: alanine residue (SEVERAL) Zn finger C2H2-type SITE: 332-356 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 362-386 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 392-414 EFFECTOR-BOUND: Zn+2 alanine-rich region {452-478} MOTIF: alanine residue (SEVERAL)

Database Correlations

UniProt P0CG40 Pfam PF00096 Entrez Gene 100131

References

UniProt :accession P0CG40