transcription factor Sp7 (zinc finger protein osterix, SP7, OSX)

Function: 1) transcriptional activator essential for osteoblast differentiation 2) binds to Sp1 & EKLF consensus sequences & to other G/C-rich sequence Structure: 1) belongs to the Sp1 C2H2-type zinc-finger protein family 2) contains 3 C2H2-type zinc fingers Compartment: nucleus

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: MW = 45 kD entity length = 431 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 294-318 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 324-348 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 354-376 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 606633 UniProt Q8TDD2 Pfam PF00096

References

UniProt :accession Q8TDD2