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transcription factor Sp4; stimulatory protein 4 (Sp4, SPR-4)
Function:
- binds to GT & GC boxes promoters elements
- probable transcriptional activator
Structure:
- belongs to the Sp1 C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression: abundant in brain
General
C2H2 type zinc finger protein
phosphoprotein
Sp1 transcription factor family
Properties
SIZE: entity length = 784 aa
MW = 82 kD
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {7-11}
MOTIF: glutamate residue (SEVERAL)
alanine-rich region {12-19}
MOTIF: alanine residue (SEVERAL)
serine-rich region {122-130}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S136}
Thr phosphorylation site {T138}
serine-rich region {185-188}
MOTIF: serine residue (SEVERAL)
Zn finger C2H2-type
SITE: 647-671
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 677-701
EFFECTOR-BOUND: Zn+2
MOTIF: Ser phosphorylation site {S691}
Zn finger C2H2-type
SITE: 707-729
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 600540
UniProt Q02446
Pfam PF00096
Entrez Gene 6671
Kegg hsa:6671
References
UniProt :accession Q02446