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transcription factor Sp2; stimulatory protein 2 (Sp2, KIAA0048)
Function:
- binds to GC box promoters elements & selectively
- activates mRNA synthesis from genes that contain functional recognition sites
Structure:
- belongs to the Sp1 C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=2
General
C2H2 type zinc finger protein
phosphoprotein
Sp1 transcription factor family
Properties
SIZE: entity length = 613 aa
MW = 65 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T192}
Zn finger C2H2-type
SITE: 525-549
EFFECTOR-BOUND: Zn+2
Thr phosphorylation site {T550}
Zn finger C2H2-type
SITE: 555-579
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 585-607
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 601801
UniProt Q02086
Pfam PF00096
Entrez Gene 6668
Kegg hsa:6668
References
UniProt :accession Q02086