transcription factor RFX4 (regulatory factor X 4, testis development protein NYD-SP10, RFX4)

Function: - may activate transcription by interacting directly to the X-box (putative) Structure: - homodimer - heterodimer with RFX2 & RFX3 - binds DNA - belongs to the RFX family Compartment: nucleus (putative) Alternative splicing: named isoforms=4 Expression: - isoform 4 is testis-specific - isoform 1 is expressed in brain & gliomas - isoform 2 & isoform 3 are testis-specific (at protein level) - isoform 1 is expressed in brain (at protein level) - isoform 3 is higher expressed in adult testes & ejaculated spermatozoa than in fetal testes

General

DNA-binding protein transcription factor (TF)

Properties

SIZE: entity length = 735 aa MW = 83 kD COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 44-126 dimerization {315-487}

Database Correlations

OMIM 603958 UniProt Q33E94 Pfam PF02257 Kegg hsa:5992

References

UniProt :accession Q33E94