transcription factor NF-E4 (NFE4)

Function: - part of the SSP complex (stage selector protein complex) - interacts with HDAC1 & PCAF - acetylation at Lys-43 prolongs the protein half-life by preventing ubiquitin-mediated degradation & diminishes interaction between NF-E4 & HDAC1, potentially maximizing activating ability of the factor - ubiquitination leads to its degradation by the proteasome - acetylation at Lys-43 prevents ubiquitination - isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 & RNA polymerase 2 recruitment to the gamma-globin gene promoter . isoform 2 interacts with TFCP2 Compartment: nucleus (probable) Alternative initiation: named isoforms=2 Expression: - specifically expressed in fetal liver, cord blood & bone marrow - also expressed in the K562 & HEL cell lines, which constitutively express the fetal globin genes

Properties

SIZE: entity length = 179 aa MW = 19 kD COMPARTMENT: cell nucleus

Database Correlations

OMIM 612133 UniProt Q86UQ8

References

UniProt :accession Q86UQ8