transcription factor MafA (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A, pancreatic beta-cell-specific transcriptional activator, transcription factor RIPE3b1, MAFA)

Function: - transcription factor that appears to have a key role in regulation of the insulin gene transcription - specifically binds the insulin enhancer element RIPE3b & activates insulin gene expression - cooperates synergistically with NEUROD1 & PDX1 - binds DNA as a homodimer (probable) - interacts with NEUROD1 & PDX1 - phosphorylated on Ser & Thr - Ser-14 & Ser-65 appear to be the major phosphorylation sites Structure: - belongs to the bZIP family. Maf subfamily - contains 1 bZIP domain Compartment: - nucleus - detected in nuclei of pancreas islet beta cells (putative) Expression: up-regulated by glucose

General

DNA-binding protein phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 352 aa MW = 37 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S14} Ser phosphorylation site {S65} glycine-rich region {74-86} histidine-rich region {147-219} MOTIF: histidine residue (SEVERAL) DNA-binding motif SITE: 253-279 leucine zipper SITE: 281-302 FOR-BINDING-VIA: leucine zipper

Database Correlations

UniProt Q8NHW3 PFAM correlations Kegg hsa:3896

References

UniProt :accession Q8NHW3