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transcription factor LBX1; ladybird homeobox protein homolog 1 (LBX1, LBX1H)
Function:
- transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord & migration & further development of hypaxial muscle precursor cells for limb muscles, diaphragm & hypoglossal cord
- interacts with SKOR1 which acts as a transcriptional corepressor (putative)
Structure:
- contains 1 homeobox DNA-binding domain
Compartment: nucleus (probable)
General
transcription factor (TF)
Properties
SIZE: entity length = 281 aa
MW = 30 kD
COMPARTMENT: cell nucleus
MOTIF: homeodomain
SITE: 125-184
glycine-rich region {220-226}
acidic region {270-281}
MOTIF: acidic residue (SEVERAL)
Database Correlations
OMIM 604255
UniProt P52954
Pfam PF00046
Entrez Gene 10660
Kegg hsa:10660
References
UniProt :accession P52954