transcription factor HES-7 (hairy & enhancer of split 7, bHLH factor Hes7, HES7)

Function: - transcriptional repressor - represses transcription from both N box- & E box-containing promoters. May with HES1, - cooperatively with HES1 regulates somite formation in presomitic mesoderm - role as a segmentation clock, essential for coordinated somite segmentation Structure: - contains 1 basic helix-loop-helix domain (bHLH) - contains 1 Orange domain Compartment: nucleus

General

hairy & enhancer of split (HES) transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 25 kD entity length = 225 aa COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 13-25 helix-loop-helix NAME: helix-loop-helix SITE: 26-70 FOR-BINDING-VIA: helix-loop-helix Orange {92-122} proline-rich region SITE: 128-225 MOTIF: proline residue (SEVERAL) WRPW {221-224}

Database Correlations

OMIM 608059 UniProt Q9BYE0 PFAM correlations

References

UniProt :accession Q9BYE0