transcription factor HES-5 (Hairy & enhancer of split 5, HES5)

Function: 1) transcriptional repressor of genes that require a bHLH protein for their transcription 2) transcription repression requires formation of a complex with a corepressor protein, Groucho 3) has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) 4) C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins Compartment: nucleus Expression: - expressed in fetal heart & brain tumors Structure: - contains 1 basic helix-loop-helix (bHLH) domain - contains 1 Orange domain

General

hairy & enhancer of split (HES) transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 18 kD entity length = 166 aa COMPARTMENT: cell nucleus MOTIF: lysine-rich region {14-31} MOTIF: lysine residue (SEVERAL) DNA-binding motif SITE: 17-29 helix-loop-helix NAME: helix-loop-helix SITE: 30-73 FOR-BINDING-VIA: helix-loop-helix Orange {88-119} proline-rich region SITE: 122-142 MOTIF: proline residue (SEVERAL) alanine-rich region {147-153} MOTIF: alanine residue (SEVERAL) WRPW {163-166}

Database Correlations

OMIM 607348 UniProt Q5TA89 PFAM correlations

References

UniProt :accession Q5TA89